منابع مشابه
Genetic modifiers of sickle cell disease.
Sickle cell disease is one of the best characterized human monogenic disorders. Complex genotype/phenotype correlations clearly demonstrate the interaction of multiple genetic and environmental factors. In the last 20 years, scientific research has applied genetic approaches to dissect some of these modifiers. This review highlights the more recent genetic association studies that have been app...
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Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...
متن کاملGenetic modifiers of liver disease in cystic fibrosis.
CONTEXT A subset (approximately 3%-5%) of patients with cystic fibrosis (CF) develops severe liver disease with portal hypertension. OBJECTIVE To assess whether any of 9 polymorphisms in 5 candidate genes (alpha(1)-antitrypsin or alpha(1)-antiprotease [SERPINA1], angiotensin-converting enzyme [ACE], glutathione S-transferase [GSTP1], mannose-binding lectin 2 [MBL2], and transforming growth fa...
متن کاملThe role of glia in neurological disease
Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2011
ISSN: 0959-437X
DOI: 10.1016/j.gde.2010.12.007